## Background: Timed sequential chemotherapy and high-dose cytarabine (cytosine arabinoside, ara-c; hdac) are both effective treatments for acute myeloid leukemia (aml). we review our institutional experience with timed sequential induction chemotherapy consisting of daunorubicin/ara-c/-thioguanine
Early results of intensified remission induction chemotherapy for childhood acute lymphocytic leukemia
โ Scribed by Rivera, Gaston K. ;George, Stephen L. ;Williams, Dorothy ;Look, A. Thomas ;Abromowitch, Minnie ;Pui, Ching-Hon ;Ochs, Judith J. ;Dahl, Gary V. ;Kalwinsky, David K. ;Mirro, Joseph ;Dow, Lois W. ;Raimondi, Susana ;Murphy, Sharon B.
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 459 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0098-1532
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Six adults with refractory acute lymphocytic leukemia (ALL) were treated with high-dose methotrexate, citrovorum factor, and vincristine. All patients had previously received extensive treatment with standard therapeutic agents, including vincristine, and all but one had received prior methotrexate.
Twenty-eight patients with acute non-lymphoblastic leukemia (ANLL) were started on induction chemotherapy consisting of Cytosine Arbinoside (Ara C) and 6 thioguanine (TG). Daunoruhicin (DNR) was used selectively in 20 of 28 patients who failed to respond by day 14 to the Ara C and TG combination. Se