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Early primary biliary cirrhosis: Biochemical response to treatment and prediction of long-term outcome

✍ Scribed by Christophe Corpechot; Olivier Chazouillères; Raoul Poupon


Book ID
116652445
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
718 KB
Volume
55
Category
Article
ISSN
0168-8278

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Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. It has been recently proposed that an alkaline phosphatase (ALP) decline of more than 40% in baseline value or a normal level after 1 year of UDCA treatment (Barcelona criteria) could se

Comment on biochemical response to ursod
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We read with interest the article by Corpechot et al. in a recent issue of HEPATOLOGY. 1 Corpechot et al. identify the absence of a biochemical response to ursodeoxycholic acid (UDCA) as an important predictive factor for death or liver transplantation in patients with primary biliary cirrhosis (PBC