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Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

✍ Scribed by Kirstin Mittelstrass; Wiebke Sauter; Albert Rosenberger; Thomas Illig; Maria Timofeeva; Norman Klopp; Hendrik Dienemann; Eckart Meese; Gerhard Sybrecht; Gabi Woelke; Mathias Cebulla; Maria Degen; Harald Morr; Peter Drings; Andreas Groeschel; Karsten Grosse Kreymborg; Karl Haeußinger; Gerd Hoeffken; Christine Schmidt; Bettina Jilge; Wilhelm Schmidt; You-Dschun Ko; Dagmar Taeuscher; Jenny Chang-Claude; Heinz-Erich Wichmann; Heike Bickeboeller; Angela Risch

Book ID
115011232
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
285 KB
Volume
8
Category
Article
ISSN
1471-2407

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✍ Hugo Sousa; Mafalda Pando; Eduardo Breda; Raquel Catarino; Rui Medeiros 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

Recent studies refer that amplification/overexpression of the principal negative regulator of p53 (Mdm2) is frequently found in several malignancies. Several studies have associated a polymorphism (SNP309 T/G) in the promoter region of MDM2 with higher levels of this protein, which will favor p53-pa