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Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms

✍ Scribed by Indranil Sinha; Kevin K. Hannawa; Jonathan L. Eliason; Gorav Ailawadi; Michael P. Deogracias; Siddharth Bethi; John W. Ford; Karen J. Roelofs; Vladimir Grigoryants; Peter K. Henke; James C. Stanley; Gilbert R. Upchurch Jr.


Book ID
113919776
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
457 KB
Volume
136
Category
Article
ISSN
0039-6060

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✍ Nor Eddine Sounni; Eugenia N. Baramova; Carine Munaut; Erik Maquoi; Francis Fran 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 778 KB

## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t