Early mouse embryo development: could epigenetics influence cell fate determination?
✍ Scribed by Amandine Henckel; Szabolcs Tóth; Philippe Arnaud
- Book ID
- 101710670
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 134 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
It is generally assumed that the developmental program of embryogenesis relies on epigenetic mechanisms. However, a mechanistic link between epigenetic marks and cell fate decisions had not been established so far. In a recent article, Torres‐Padilla and colleagues1 show that epigenetic information and, more precisely, histone arginine methylation mediated by CARM1 could contribute to cell fate decisions in the mouse 4‐cell‐stage embryo. It provides the first indications that global epigenetic information influences allocation of pluripotent cells toward the first cell lineages. BioEssays 29:520–524, 2007. © 2007 Wiley Periodicals, Inc.