𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Early inhibition of nitric oxide production increases HSV-1 intranasal infection

✍ Scribed by Gisela Gamba; Hernan Cavalieri; Maria C. Courreges; Ernesto J. Massouh; Fabian Benencia

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
302 KB
Volume
73
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Here, we studied the role of nitric oxide (NO) production during the first steps of the respiratory infection of BALB/c mice with herpes simplex virus type 1 (HSV‐1), strain F. Nitric oxide synthase II (NOS‐II) mRNA and protein were detected by reverse transcription (RT)‐PCR and dot blot, respectively in samples of lungs and turbinates early post‐infection (p.i.). Immunohistochemical analysis revealed pulmonar macrophages and PMN expressing NOS‐II in the lungs of infected animals. Animals intranasally treated with aminoguanidine (AG), a NOS inhibitor, during the first steps of infection, showed a dose‐dependent increase in pneumonitis compared to controls. Viral titres in turbinates, lungs, and brains were higher in AG treated mice. Finally, histopathology studies revealed a stronger inflammation in eyes, and lungs of these animals. Taken together, these results suggest a role of NO in controlling primary HSV intranasal infection. J. Med. Virol. 73:313–322, 2004. © 2004 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Increase in experimental pulmonary metas
Increase in experimental pulmonary metastasis in mice by L-arginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester
✍ Takashi Yamamoto; Nobuyuki Terada; Akitoshi Seiyama; Yasuko Nishizawa; Hitoshi A 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 59 KB 👁 1 views

As we have previously reported, intraperitoneal injections of NG-nitro-L-arginine methyl ester [L-NAME; a competitive inhibitor of nitric oxide (NO) synthase] before and after the injection of B16 melanoma cells through a tail vein increased experimental pulmonary metastasis, while simultaneous inje

Dioscorealide B suppresses LPS-induced n
Dioscorealide B suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages: The inhibition of NF-κB and ERK1/2 activation
✍ Poonsit Hiransai; Suvina Ratanachaiyavong; Arunporn Itharat; Potchanapond Graidi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 351 KB

## Abstract Dioscorealide B (DB), a naphthofuranoxepin has been purified from an ethanolic extract of the rhizome of __Dioscorea membranacea__ Pierre ex Prain & Burkill which has been used to treat inflammation and cancer in Thai Traditional Medicine. Previously, DB has been reported to have anti‐i

The peroxisome proliferator-activated re
The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells
✍ Ronald B. Tjalkens; Xuhong Liu; Brianne Mohl; Tyler Wright; Julie A. Moreno; Dav 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

## Abstract Reactive astrogliosis is a prominent neuropathologic feature of manganism, a neurodegenerative disorder caused by excessive accumulation of manganese (Mn) in the basal ganglia. Activation of astrocytes has been linked to neuronal injury in manganism resulting from overproduction of infl