Early expression of E-selectin, tumor necrosis factor α, and mast cell infiltration in the salivary glands of patients with systemic sclerosis
✍ Scribed by Mohamed Hebbar; Jean-Michel Gillot; Eric Hachulla; Philippe Lassalle; Pierre-Yves Hatron; Bernard Devulder; Anne Janin
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 470 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Objective. To assess the predictive value of early endothelial E-selectin and tumor necrosis factor a (TNFa) expression, as well as mast cell infiltration, in the subsequent progression to systemic sclerosis (SSc) in patients with Raynaud's phenomenon (RP) and abnormal nailfold capillaroscopic findings.
Methods. Clinical criteria were evaluated, and immunostaining was performed on lip biopsy samples from 22 patients with RP and abnohnal capillaroscopic results. None of these patients initially fulfilled the American College of Rheumatology criteria for SSc.
Results. E-selectin, TNFa, and mast cell infiltration were found in 9, 10, and 8 of 11 patients, respectively, whose disease progressed to SSc, and in 0,2, and 1 of 11 patients, respectively, whose disease did not progress to SSc (P < 0.001, P < 0.01, and P < 0.01, respectively).
Conclusion. E-selectin, TNFa, and mast cell infiltration are detectable in the very early stages of SSc, prior to the onset of skin changes.
Raynaud's phenomenon (RP) is a frequently occurring disorder that is generally classified as either primary (Raynaud's disease) or secondary (1). In secondary RP, the main underlying disorders are connective tissue diseases, primarily systemic sclerosis (SSc) (2,3). In some patients, R P can precede the development of SSc by several months or years. In these patients, detection of abnormalities on nailfold capillaroscopy is a predictive marker for progression to SSc (4).