Early events during primary activation of T cells: antigen receptor cross-linking and interleukin 1 initiate proliferative response of human T cells

Cross-linking of the T cell receptor com

Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells

✍ Frank Emmrich; Lothar Kanz; Klaus Eichmann 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 661 KB

Nonpolymorphic interactions between the T cell differentiation antigens CD4 or CD8 and major histocompatibility complex (MHC)-encoded molecules have been postulated to participate in antigen recognition of MHC-restricted T cells. This would imply simultaneous binding of CD418 and of the T cell recep