Early disturbance of calcium translocation across the plasma membrane in toxic liver injury

Role of cellular calcium homeostasis in

Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenaltrans-4-OH-2-hexenal

✍ Griffin, Donna S. ;Segall, H. J. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 699 KB

The pyrrolizidine alkaloid senecionine has been shown to be hepatotoxic, genotoxic, and cytotoxic. However, the biochemical mechanism by which senecionine produces hepatocellular toxicity remains to be elucidated. The role of calcium homeostasis in toxic liver injury was examined in isolated rat hep