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Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease

โœ Scribed by Maria Gulinello; Fengying Chen; Kostantin Dobrenis


Book ID
116285059
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
395 KB
Volume
193
Category
Article
ISSN
0166-4328

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## Abstract Sandhoff's disease is a lysosomal storage disease in which the ganglioside GM2 accumulates in lysosomes. It has been reported that MRI cannot detect abnormalities in spin echo images in clinically presymptomatic Sandhoff's disease patients. Because one of the results of GM2 accumulation