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Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis

✍ Scribed by Y. Manabe; H. Warita; T. Murakami; M. Shiote; T. Hayashi; N. Omori; I. Nagano; M. Shoji; K. Abe


Book ID
113997969
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
454 KB
Volume
935
Category
Article
ISSN
0006-8993

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## Abstract Microglial activation occurs early during the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent evidence indicates that the expression of mutant Cu^2+^/Zn^2+^ superoxide dismutase 1 (SOD1) in microglia contributes to the late disease progression of ALS. However, the mechanism