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Early cognitive decline is associated with prion protein codon 129 polymorphism

โœ Scribed by Esther A. Croes; Bart Dermaut; Jeanine J. Houwing-Duistermaat; Marleen Van den Broeck; Marc Cruts; Monique M. B. Breteler; Albert Hofman; Christine van Broeckhoven; Cornelia M. van Duijn


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
73 KB
Volume
54
Category
Article
ISSN
0364-5134

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## Abstract Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease. Purine nucleotides and nucleosides play an important role in the brain. Besides th