✦ LIBER ✦

Early appearance of a lymphoid arming factor and cytotoxic lymph-node cells after tumor induction

✍ Scribed by Sylvia Pollack; Karen Nelson

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 499 KB
Volume: 14
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910140412

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✦ Synopsis

Abstract

An arming factor which collaborates with non‐sensitized lymphoid cells to produce specific killing of tumor cells in vitro appears in the serum within 24‐48 after initiation of a tumor by inoculation of Moloney Sarcoma Virus or a transplant of syngeneic sarcoma cells. Lymph‐node cells taken 1 or 2 days after tumor induction are also specifically cytotoxic in a microcytotoxicity assay. The production of this arming factor and the appearance of cytotoxic lymphoid cells are thus temporally related and are among the early responses to syngeneic sarcomas in BALB/c mice.

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Evidence for two factors in sera of tumo

Evidence for two factors in sera of tumor-immunized mice which induce specific lymphoid cell-dependent cytotoxicity: IgG2 and a rapidly appearing factor not associated with IgG or IgM

✍ Sylvia B. Pollack; Karen Nelson 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 600 KB

## Abstract As previously shown, sera from tumor‐bearing mice can induce specific antiserum‐dependent lymphoid cell‐mediated cytotoxicity (ADC) to syngeneic tumor cells in vitro. The ADC activity in such sera is now shown to be removed by adsorption of the sera to Sepharose‐linked rabbit anti‐mouse