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Early and Late Gene Changes in MPTP Mice Model of Parkinson's Disease Employing cDNA Microarray

✍ Scribed by Silvia Mandel; Edna Grünblatt; Gila Maor; Moussa B. H. Youdim

Book ID: 110402723
Publisher: Springer
Year: 2002
Tongue: English
Weight: 764 KB
Volume: 27
Category: Article
ISSN: 0364-3190
DOI: 10.1023/a:1020989812576

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## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) inhibit the mitochondrial