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Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling

✍ Scribed by Mitsunori Miyazaki; John J. McCarthy; Mark J. Fedele; Karyn A. Esser


Book ID
110117570
Publisher
Cambridge University Press
Year
2011
Tongue
English
Weight
822 KB
Volume
589
Category
Article
ISSN
0022-3751

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## Abstract Phosphatidylinositol 3‐kinase (PI3K)/Akt and nuclear factor‐kappa B (NF‐κB) signaling pathways play a critical role in mediating survival signals. In this study we have investigated how loss of dystrophin (the primary cause of Duchenne muscular dystrophy) modulates the activation of PI3