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E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3

✍ Scribed by Ying Zhou; Lu Li; Qiongming Liu; Guichun Xing; Xuezhang Kuai; Jing Sun; Xiushan Yin; Jian Wang; Lingqiang Zhang; Fuchu He

Book ID
113528176
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
346 KB
Volume
20
Category
Article
ISSN
0898-6568

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## Abstract E6‐associated protein (E6AP) is a cellular ubiquitin protein ligase that mediates ubiquitylation and degradation of tumor suppressor p53 in conjunction with the high‐risk human papillomavirus E6 protein. We previously reported that E6AP targets annexin A1 protein for ubiquitin‐dependent