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E-p-Methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate

✍ Scribed by So Ra Kim; Sang Hyun Sung; Young Pyo Jang; George J Markelonis; Tae H Oh; Young Choong Kim

Book ID: 110007165
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 374 KB
Volume: 135
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0704576

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## Abstract The glutamate uptake inhibitor L‐__trans__‐2,4‐pyrrolidine‐dicarboxylate (PDC) induces glutamate accumulation and neuronal damage in cultured cells. We have used dissociated cortical cells in culture to study whether the toxicity induced by inhibiting glutamate uptake with PDC could be