## Abstract Gallbladder carcinoma (GBC) is a highly malignant neoplasm and represents the leading cause of cancer death in Chilean women. In order to determine the potential role of promoter methylation in gallbladder carcinogenesis, we investigated the frequency of this epigenetic mechanism by met
E-Cadherin Promoter Hypermethylation in Preneoplastic and Neoplastic Skin Lesions
โ Scribed by Chiles, M. C.
- Book ID
- 110088451
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 146 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0893-3952
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Several studies have shown that Eโcadherin expression is lost during malignant transformation. We hypothesized that CpG methylation in the promoter region may inactivate the expression of the Eโcadherin gene in human bladder cancer. Normal and bladder cancer samples from 51 patients wer
## Abstract Promoter hypermethylation of various tumorโrelated genes is extremely frequent in EpsteinโBarr virus (EBV)โassociated gastric carcinoma (EBVaGC). To investigate the significance of the promoter methylation in EBVaGC, we focused on one of the important proteins in the carcinogenesis of t
## Abstract ## BACKGROUND Loss of Eโcadherin expression is associated with aberrant 5โฒ CpG island methylation in various tumors. ## METHODS The authors analyzed the methylation status and immunohistochemical expression of Eโcadherin in 142 endometrial tissues, consisting of 21 normal endometria,
We previously isolated the 5' upstream sequences of the mouse P-cadherin gene, in which putative binding sites for several transcription factors were identified between nt-101 and +30. In the study reported here, the promoter activity of the postulated 5' cis-acting sequences of the P-cadherin promo