E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast
โ Scribed by Mastracci, Teresa L; Tjan, Suzanna; Bane, Anita L; O'Malley, Frances P; Andrulis, Irene L
- Book ID
- 109888194
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 666 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0893-3952
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Lobular carcinoma in situ (LCIS) of the breast is commonly identified as an incidental finding in breast biopsies performed because of either a mammographic abnormality or a palpable mass. Although long recognized as an entity, the significance and optimal treatment of LCIS remains controversial. In
## Loss of expression of the intercellular adhesion molecule E-cadherin frequently occurs in invasive lobular breast carcinomas as a result of mutational inactivation. Expression patterns of E-cadherin and the molecules comprising the cytoplasmic complex of adherens junctions, -, -and -catenin, we