A boy with a Becker muscular dystrophy (BMD) phenotype presented unique muscular dystrophin expression. Western blot analysis showed the presence of two dystrophins of different sizes, i.e., a 400-kDa dystrophin and a 500-kDa form. An immunofluorescent study revealed mosaic expression of these dystr
Dystrophin Abnormality in Progressive Muscular Dystrophy -A Review Article-
β Scribed by Kiichi Arahata
- Book ID
- 118711630
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 910 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1328-8067
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The mdx mouse has a mutated dystrophin gene and is used as a model for the study of Duchenne muscular dystrophy (DMD). We investigated whether regenerating mdx skeletal muscle contains the extracellular matrix protein tenascin-C (TN-C), which is expressed in wound healing and nerve regeneration. Pri
Immunohistochemical localization of dystrophin was studied in a symptomatic carrier of Becker muscular dystrophy (BMD). Muscle biopsy specimens from a female carrier showed findings compatible with slowly progressive muscular dystrophy by ordinary histochemical examinations. Immunohistochemical stud