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Dystrophia Myotonica: Identification of Heterozygotes


Book ID
123335768
Publisher
The Lancet
Year
1970
Tongue
English
Weight
296 KB
Volume
296
Category
Article
ISSN
0140-6736

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Structure of dystrophia myotonica protei
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## Abstract Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled‐coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM‐8) revealed a dimeric enz