Dysregulation of potentially pathogenic self reactivity is crucial for the manifestation of clinical autoimmunity

✍ Scribed by V. Kumar; E. Sercarz

• Book ID: 102652214
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 634 KB
• Volume: 45
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/(sici)1097-4547(19960815)45:4<334::aid-jnr2>3.0.co;2-a

✦ Synopsis

During the evolution of the autoimmune response to myelin basic protein (MBP), at least two distinct lymphocyte populations arise, one that is specific for determinants within the protein antigen and another that is specific for the receptors displayed by the antigenspecific lymphocytes themselves. The T-cell receptor (TCR)-specific lymphocytes appear to oppose the action of the pathogenic effector cells, which predominantly utilize the TCR VpS.2 gene segment. We will discuss our work suggesting that both CD4 and CDS cells specific for different TCR determinants on the Vp8.2 chain are involved in the regulation of MBPspecific CD4 T cells mediating experimental autoimmune encephalomyelitis. We suggest that a crucial balance between the effectors and regulators is decisive for the clinical manifestation of autoimmunity.