ST2-3T3, a spontaneously transformed BALBk-3T3 cell line which does not require platelet-derived growth factor (PDGF) for growth, was fused to THOz, a PDGF-responsive non-transformed BALBlc-3T3 cell line, in order to learn whether transformation is expressed coordinately with PDGF independence. Hybr
DYSREGULATION OF GROWTH FACTOR-RECEPTOR SYSTEM IN CELLULAR TRANSFORMATION
β Scribed by Hatakeyama, Masanori ;Taniguchi, Tadatsugu
- Book ID
- 108578638
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1988
- Tongue
- English
- Weight
- 953 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0910-5050
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## Abstract ## Objective As an initial approach to understanding the basis of the systemic sclerosis (SSc; scleroderma) phenotype, we sought to identify genes in the transforming growth factor Ξ² (TGFΞ²) signaling pathway that are upβregulated in lesional SSc fibroblasts relative to their normal cou