Dyskinesias and dopamine cell replacement in Parkinson's disease: a clinical perspective
β Scribed by Peter Hagell; M. Angela Cenci
- Book ID
- 116326076
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 289 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0361-9230
No coin nor oath required. For personal study only.
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Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing-off and on-off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The ma
## Abstract Dyskinesias following longβterm dopamine replacement therapy are a major limitation of current treatments for Parkinson's disease. Recently, attention has been focused on the concept of using nonβdopaminergic adjuncts to currently available therapies in an attempt to reduce the problem