Dysfunctional FOXP3 + Regulatory T cells in Leukocyte Adhesion Deficiency Type 1 (LAD-1) Patients with Reversion Mutations and Inflammatory Bowel Disease

Functional type 1 regulatory T cells dev

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome

✍ Laura Passerini; Sara Di Nunzio; Silvia Gregori; Eleonora Gambineri; Massimilian 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 438 KB

Mutations of forkhead box p3 (__FOXP3__), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The rel