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Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly

✍ Scribed by Qin Ouyang; Wolfgang M Wagner; Wei Zheng; Anders Wikby; Ed J Remarque; Graham Pawelec


Book ID
113614410
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
156 KB
Volume
39
Category
Article
ISSN
0531-5565

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Efficient protocols to generate cytomegalovirus (CMV)-specific T cells are required for adoptive immunotherapy. Recombinant Epstein-Barr virus (EBV) vectors called mini-EBV can be used to establish permanent B cell lines in a single step, which present the CMV antigen pp65 in a constitutive manner.