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Dynamics of Resin-Bound Cholate Ions Studied by Deuterium NMR Spectroscopy

✍ Scribed by Yim, C. T.; Brown, G. R.; Morin, F. G.

Book ID
126323604
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
174 KB
Volume
13
Category
Article
ISSN
0743-7463

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We have employed deuterium NMR techniques to determine the dynamics of trimethoprim (TMP) in a binary complex with dihydrofolate reductase (DHFR) or in a ternary complex with DHFR and cofactor NADP+ in the fully hydrated state. TMP was deuterated at the following positions: (2',6'-D2)TMP, (3'-Ome-D3