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Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1

✍ Scribed by Ryuji Yamaguchi; Guy Perkins

Book ID
113484380
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
593 KB
Volume
1787
Category
Article
ISSN
0005-2728

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## Abstract To characterize the molecular links between type‐1 autosomal dominant optic atrophy (ADOA) and OPA1 dysfunctions, the effects of pathogenic alleles of this dynamin on mitochondrial morphology and apoptosis were analyzed, either in fibroblasts from affected individuals, or in HeLa cells