Dynamics of hepatitis B virus resistance to entecavir in a nucleoside/nucleotide-naïve patient
✍ Scribed by Jin-Jun Guo; Qing-Ling Li; Xiao-Feng Shi; Da-Zhi Zhang; Ai-Zhong Zeng; Tao Feng; Ai-Long Huang
- Book ID
- 113457869
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 252 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0166-3542
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📜 SIMILAR VOLUMES
a HBV DNA Ͻ7 ϫ 10 5 copies/mL by bDNA assay ϩ loss of HBeAg (Study AI463022) or normalization of ALT (Study AI463027). b HBV DNA Ͻ7 ϫ 10 5 copies/mL by bDNA assay. c HBV DNA Ն7 ϫ 10 5 copies/mL by bDNA assay.
Patients with chronic hepatitis B virus (HBV) infection who develop antiviral resistance lose benefits of therapy and may be predisposed to further resistance. Entecavir (ETV) resistance (ETVr) results from HBV reverse transcriptase substitutions at positions T184, S202, or M250, which emerge in the