Dynamics of Genome Change in the E2/NS1 Region of Hepatitis C Virus in Vivo
β Scribed by Yasuyuki Higashi; Shinichi Kakumu; Kentaro Yoshioka; Takaji Wakita; Masashi Mizokami; Kenichi Ohba; Yuji Ito; Tetsuya Ishikawa; Masahiro Takayanagi; Yoshiyuki Nagai
- Book ID
- 112269479
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 509 KB
- Volume
- 197
- Category
- Article
- ISSN
- 0042-6822
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## Abstract Hepatitis C virus (HCV) infection is characterized by persistence of liver inflammation that often leads to endβstage liver disease, although the mechanisms are not fully understood. A hyperβvariable region (HVR) has been reported in the E2/NS1 region of the HCV genome, in which strikin
GB virus C/hepatitis G virus (GBV-C/HGV) is related distantly to hepatitis C virus (HCV). HCV has a hypervariable region (HVR), and exists as quasispecies in vivo. Although GBV-C/HGV also has replaceable amino acids in the presumed antigenic region, the existence and fluctuation of population of het