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Dynamics of Epstein-Barr virus load in pyothorax-associated lymphoma

✍ Scribed by Kotaro Shide; Hideho Henzan; Koji Nagafuji; Kenichi Aoki; Toshihiro Miyamoto; Kazuya Shimoda; Yukumasa Kazuyama; Koichi Ohshima; Hisashi Gondo; Mine Harada

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
85 KB
Volume
70
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

We treated a 73‐year‐old man who developed a pyothorax‐associated pleural lymphoma after a 52‐year history of tuberculous pleuritis. The lymphoma was classified histologically as a diffuse large, B‐cell type. Epstein‐Barr virus (EBV) was identified in the tumor by immunocytochemical and molecular methods. Chemotherapy both without and with the addition of rituximab was only minimally effective, but adding radiotherapy to chemotherapy reduced the tumor size, resulting in a partial remission. The EBV load measured by a quantitative real‐time polymerase chain reaction correlated well with the tumor size and the serum lactate dehydrogenase concentration. Monitoring the EBV load may be useful in the management of pyothorax‐associated lymphoma. J. Med. Virol. 70:137–140, 2003. © 2003 Wiley‐Liss, Inc.

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