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Dynamical binding of proline-rich peptides to their recognition domains

✍ Scribed by Wei Gu; Volkhard Helms

Book ID
104003468
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
334 KB
Volume
1754
Category
Article
ISSN
1570-9639

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✦ Synopsis

Recognition of proline-rich sequences plays an important role for the assembly of multi-protein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that share characteristic features. For many complex systems containing proline-rich sequences, multiple binding modes have been found by theoretical and/or experimental studies. In this review, we discuss the different binding modes as well as the correlated dynamics of the peptides and their recognition domains, and some implications to their biological functions. Furthermore, we give an outlook of the systems in the context of systems biology.

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