Dynamic water changes in excised rat myocardium assessed by continuous distribution of T1 and T2

✍ Scribed by Morten Bruvold; John Georg Seland; Heidi Brurok; Per Jynge

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 402 KB
• Volume: 58
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.21340

✦ Synopsis

Abstract

Ischemic changes in excised rat myocardium were followed by series of T~1~ or T~2~ measurements from 1 to 60 min after isolated perfusion cessation, and the influence of manganese enhancement was investigated. An inverse Laplace transformation (ILT) of T~1~ or T~2~ data was used to resolve the number, time constants, and fractions of tissue water components in a continuous distribution. For T~1~ distributions, one single tissue component ∼900 ms was significantly shortened and dispersed by manganese enhancement (25 and 200 μM MnCl~2~). For T~2~ distributions, three tissue components (∼30, ∼100, and ∼350 ms) were obtained initially. The two shortest components merged after ∼10 min to one component (∼40 ms). Both T~1~ and T~2~ tissue components became shorter with time. In particular, the T~2~ distribution dynamics might be compatible with complex sequential changes in tissue water fractions during ischemia. Magn Reson Med 58:442–447, 2007. © 2007 Wiley‐Liss, Inc.