Dynamic T1-weighted magnetic resonance imaging of interstitial laser photocoagulation in the liver: Observations on in vivo temperature sensitivity
✍ Scribed by Fried, Marvin P.; Morrison, Paul R.; Hushek, Stephen G.; Kernahan, Gilberto A.; Jolesz, Ferenc A.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 976 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
Background and Objective: Magnetic resonance imaging's (MRI) potential to monitor interstitial laser photocoagulation (ILP) has been previously demonstrated and is further tested here with improved spatial and temporal resolution. Study DesigniMaterials and Methods: In vivo experiments employed fiber-delivered 1,064 nm light (3.0 W, 150 sec) in six rabbit livers monitored under T1-weighted FSE MRI as 1 image/lO sec and a 3 mm thick 8 cm FOV. Image signal intensities (SI) were compared with temperatures (T) at 7,10, and 15 nun from the fiber.
Results: Data showed 33°C < T < 60°C. SI did not vary inverselinearly with T; changes in the tissue altered the MRI signal interfering with the SI changes due to temperature. Conclusion: MRI cannot map SI-derived temperatures over the entire treatment site. The role of MRI's temperature sensitivity must be coordinated with organ-and dose-specific tissue changes.