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Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage

✍ Scribed by Jean-François Haince; Marie-Eve Ouellet; Darin McDonald; Michael J. Hendzel; Guy G. Poirier


Book ID
113485838
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
746 KB
Volume
1763
Category
Article
ISSN
0167-4889

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Effect of a poly(ADP-ribose) polymerase
✍ Luísa Cristóvão; José Rueff 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 695 KB

The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the