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Dynamic property of intermediate filaments: Regulation by phosphorylation

✍ Scribed by Masaki Inagaki; Yoichiro Matsuoka; Kunio Tsujimura; Shoji Ando; Toshiya Tokui; Toshitada Takahashi; Naoyuki Inagaki


Book ID
102758430
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
894 KB
Volume
18
Category
Article
ISSN
0265-9247

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✦ Synopsis


Site-specific phosphorylation of intermediate filament (IF) proteins on serine and threonine residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation. Thus, IF phosphorylation appears to be one of the most predominant strategies in coordinating intracellular organization of the IF Accepted


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