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Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork

✍ Scribed by Lenne, Pierre-François; Wawrezinieck, Laure; Conchonaud, Fabien; Wurtz, Olivier; Boned, Annie; Guo, Xiao-Jun; Rigneault, Hervé; He, Hai-Tao; Marguet, Didier


Book ID
110031598
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
372 KB
Volume
25
Category
Article
ISSN
0261-4189

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When neuroblastoma cells are exposed to lysophosphatidic acid (LPA), they undergo a vigorous, but transient blebbing phase. The effect is sensitive to inhibition by staurosporine, KT 5926 (an inhibitor of myosin light chain kinase), and cytochalasin B, suggesting that LPA activates the phosphorylati