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Dynamic modeling of cellular response to DNA damage based on p53 stress response networks

โœ Scribed by Jinpeng Qi; Yongsheng Ding; Shihuang Shao

Book ID
113855980
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
520 KB
Volume
19
Category
Article
ISSN
1002-0071

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## Abstract It is generally accepted that exposure of cells to a variety of DNAโ€damaging agents leads to upโ€regulation and activation of wildโ€type (wt) p53 protein. We investigated the (re)โ€activation of p53 protein in two human cancer cell lines in which the gene for this tumor suppressor is not m