Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction

✍ Scribed by Ben T. Chen; G. Allan Johnson

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 596 KB
• Volume: 52
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.20251

✦ Synopsis

Abstract

Hyperpolarized (HP) ^3^helium (^3^He) dynamic MRI was used to investigate airway response in rats following intravenous (i.v.) bolus administration of a contractile agent, methacholine (MCh). The method provides direct visualization of the ventilated regions within the lung. Heterogeneous bronchoconstriction following the i.v. MCh injection was evident using this technique. These ^3^He dynamic lung images revealed that the inspired fresh air was shunted to the less‐constricted regions after the MCh challenge in a similar manner as described by Laplace's relationship for the stability between adjacent alveoli. The airways in the more‐constricted regions became nearly closed, resulting in air trapping, while the airways in the less‐constricted regions remained effectively open, leading to overinflation. These data suggest a lung model of airway constriction partitioned into ventilated and nonventilated regions. These nonventilated regions are heterogeneously distributed in the lung and this distribution cannot be deduced from spirometric measurement of the whole lung. We demonstrate that a combination of functional ^3^He images and anatomical ^1^H images provide an effective method to diagnose regional lung abnormalities in rats. Magn Reson Med 52:1080–1086, 2004. © 2004 Wiley‐Liss, Inc.