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Dynamic expression of FXYD6 in the inner ear suggests a role of the protein in endolymph homeostasis and neuronal activity

✍ Scribed by Benjamin Delprat; Jean-Luc Puel; Käthi Geering


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
534 KB
Volume
236
Category
Article
ISSN
1058-8388

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## Abstract Mutations in the gene encoding ClC‐5 lead to X‐linked hypercalciuric nephrolithiasis (XLHN), characterized by proteinuria, hypercalciuria, and phosphaturia. In renal proximal tubule cells, ClC‐5 was identified as an important player in endocytosis, which ensures reabsorption of filtered