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Dynamic electron spin resonance (ESR) imaging of the distribution of spin labeled dextran in a mouse

✍ Scribed by Shunsuke Kazama; Gou Takashige; Hisashi Yoshioka; Hisayuki Tanizawa; Tateaki Ogata; Janusz Koscielniak; Lawrence J. Berliner

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
456 KB
Volume
36
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The nitroxide group 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) was covalently bound to a dextran via an N‐acetamido linkage to produce a novel spin probe, TEMPO‐dextran (TEMPO‐DX), which circulates for long time periods in an animal without metabolic degradation. TEMPO‐DX was stable in mice, while small TEMPO analogs quickly disappeared after administration. Since dextran was reduced somewhat in size during synthesis, the resultant spin‐labeled dextran could be excreted through the kidney. A strong L‐band electron spin resonance signal was obtained shortly after Intravenous administration of TEMPO‐DX into the tail vein of a mouse, from which three‐dimensional images of specific organs were calculated. The signal was found to persist for well over 1 h.

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