Dynamic dephasing changes in developing ischemic cerebral infarction in rats studied by Carr–Purcell T2 magnetic resonance imaging
✍ Scribed by Martin Kavec; Olli H. J. Gröhn; Heidi I. Gröhn; Michael Garwood; Risto A. Kauppinen
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 322 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Carr–Purcell (CP) T~2~ MRI with adiabatic pulses, acquired with varying interecho interval (τ~CP~), was used to study the time course of T~2~ and relative dynamic‐dephasing contrast in the rat brain. Exposure to 30 min of middle cerebral artery occlusion (MCAo) resulted in an irreversible increase in absolute CP‐T~2~ relaxation times. This was not associated with signal change in the relative dynamic‐dephasing images, as computed by subtracting short τ~CP~ CP‐T~2~ images from long τ~CP~ images and normalizing for long τ~CP~ images. A day after MCAo strong CP‐T~2~ hyperintensity and low apparent diffusion coefficient were evident in the striatum with a decline in relative dynamic‐dephasing contrast. Low dynamic dephasing contrast prevailed in striatum until day 5 post‐MCAo, returning to control levels with similar time course to normalizing T~2~ and diffusion. The present results show a novel behavior of dynamic‐dephasing contrast in poststroke brain tissue, providing data to assess the age of infarction in association to T~2~ images. Magn Reson Med 53:960–964, 2005. © 2005 Wiley‐Liss, Inc.