Dynamic contrast-enhanced MRI of primary rectal cancer: Quantitative correlation with positron emission tomography/computed tomography

✍ Scribed by Jing Gu; Pek-Lan Khong; Silun Wang; Queenie Chan; Ed X. Wu; Wailun Law; Rico Kingyin Liu; Jingbo Zhang

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 316 KB
• Volume: 33
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.22405

✦ Synopsis

Abstract

Purpose

To assess the correlations between parameters measured on dynamic contrast‐enhanced magnetic resonance imaging and 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) in rectal cancer.

Materials and Methods

To assess the correlations between parameters measured on dynamic contrast‐enhanced MRI and FDG‐PET in rectal cancer.

Results

Significant correlations were only demonstrated between k~ep~ and SUVmax (r = 0.587, P = 0.001), and k~ep~ and SUVmean (r = 0.562, P = 0.002). No significant differences were found in imaging parameters between well, moderately and poorly differentiated adenocarcinoma groups. However, there was a trend that higher imaging values were found in poorly differentiated adenocarcinomas.

Conclusion

Positive correlations were found between k~ep~ and SUV values in primary rectal adenocarcinomas suggesting an association between angiogenesis and metabolic activity and further reflecting that angiogenic activity in washout phase is better associated with tumor metabolism than the uptake phase. J. Magn. Reson. Imaging 2011;33:340–347. © 2011 Wiley‐Liss, Inc.