𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dynamic contrast-enhanced MR imaging for differentiation of rounded atelectasis from neoplasm

✍ Scribed by Michael Horn; Markus Oechsner; Marianna Gardarsdottir; Herbert Köstler; Markus F. Müller

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
361 KB
Volume
31
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To characterize rounded atelectasis (RA) with dynamic contrast‐enhanced MRI in the differential diagnosis of solitary peripheral pulmonary neoplasm.

Materials and Methods

Twenty‐four patients with diagnostically equivocal peripheral pulmonary nodules were examined with dynamic contrast‐enhanced MRI. 13 patients had a total of 16 rounded atelectases and 11 had a neoplasm. The final diagnosis was made either by histology (n = 14) or follow‐up examinations of at least 24 months (n = 10). The peripheral nodules were evaluated concerning their morphology and contrast‐enhancement dynamics. Curves for signal intensity (SI) versus time were produced and the relative increase in SI, slope of SI during wash‐in, and slope of SI during wash‐out calculated. Additionally, SI time curves were evaluated using a two compartment model where the ratio for the SI of the fast and the slow component were calculated. Mean values from different tissues of interest were compared by an unpaired two‐sided t‐test.

Results

Analysis of the SI‐time curves of the RAs revealed a curve shape similar to the pulmonary artery, but a magnitude in SI between artery and normal lung tissue. Linear curve fit showed a significantly steeper slope during wash‐in and wash‐out, and higher relative signal increase in atelectases as compared to neoplasms. Results from the two compartment model showed increased flow and a high ratio of the slow to the fast components with a long mean transit time in neoplasms.

Conclusion

Three parameters, slope of SI during wash‐in and wash‐out, and the slow/fast ratio can be used as diagnostic tools for discrimination of RA and neoplasm. J. Magn. Reson. Imaging 2010;31:1364–1370. © 2010 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Algorithms for calculation of kinetic pa
Algorithms for calculation of kinetic parameters from T1-weighted dynamic contrast-enhanced magnetic resonance imaging
✍ Mark A. Horsfield; Bruno Morgan 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB

## Abstract ## Purpose To quantify the errors involved in calculating dynamic parameters (__K__^trans^ and __v__~__e__~) from dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) scans, and to develop alternative analyses to improve accuracy or increase processing speed. ## Materials an

Determination of arterial input function
Determination of arterial input function using fuzzy clustering for quantification of cerebral blood flow with dynamic susceptibility contrast-enhanced MR imaging
✍ Kenya Murase; Keiichi Kikuchi; Hitoshi Miki; Teruhiko Shimizu; Junpei Ikezoe 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB 👁 1 views

## Abstract An accurate determination of the arterial input function (AIF) is necessary for quantification of cerebral blood flow (CBF) using dynamic susceptibility contrast‐enhanced magnetic resonance imaging. In this study, we developed a method for obtaining the AIF automatically using fuzzy c‐m

Contrast-enhanced MRI combined with MR c
Contrast-enhanced MRI combined with MR cholangiopancreatography for the evaluation of patients with biliary strictures: Differentiation of malignant from benign bile duct strictures
✍ Ji Yang Kim; Jeong Min Lee; Joon Koo Han; Se Hyung Kim; Jae Young Lee; Jin Young 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB

## Abstract ## Purpose To determine imaging criteria for the combined use of contrast‐enhanced (CE)‐MRI and MR cholangiopancreatography (MRCP) to differentiate malignant from benign biliary strictures. ## Materials and Methods A total of 44 patients with biliary stricture who had undergone unenh