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Dynamic contrast-enhanced magnetic resonance imaging: A useful tool for characterizing ovarian epithelial tumors

✍ Scribed by Isabelle Thomassin-Naggara; Emile Daraï; Charles A Cuenod; Roman Rouzier; Patrice Callard; Marc Bazot

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
626 KB
Volume
28
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To evaluate the utility of dynamic contrast enhancement (DCE) MRI for distinguishing among benign, borderline and invasive epithelial ovarian tumors.

Materials and Methods

We analyzed preoperative MRI studies of 37 patients with ovarian epithelial tumors (10 benign, 11 borderline, and 16 invasive). A DCE‐MRI sequence was acquired and regions of interest (ROIs) were drawn in the ovarian tumors and adjacent myometrium. A total of three patterns of enhancement were defined. Dynamic data were parameterized using mathematical models that included the enhancement amplitude (EA), the time of half rising (THR), and the maximal slope (MS). Using myometrium as the internal reference, ratios of EA (EAr), THR (THRr), MS (MSr), and initial area under the curve for 60 seconds after injection (IAUC~60~ ratio) were determined.

Results

Morphological criteria such as septa, papillary projection, solid portion, and T2‐weighted MR signal intensity of solid tissue were useful for discriminating invasive from noninvasive ovarian tumors (P = 0.01, P = 0.02, P = 0.002, and P < 0.0001 respectively) but not for discriminating benign from borderline tumors. Curve type 3 was specific for invasive ovarian tumors. EAr, MSr, and IAUC~60~ ratio were higher for invasive than for benign (P < 0.0001) and borderline tumors (P = 0.005, P = 0.002, and P = 0.001, respectively). The IAU~60~ ratio was the most relevant factor for discriminating benign from borderline and invasive tumors. MSr and IAU~60~ ratio could be combined to generate a decision tree with 81% accuracy.

Conclusion

DCE‐MRI is a useful tool for characterizing epithelial ovarian tumors. J. Magn. Reson. Imaging 2008;28:111–120. © 2008 Wiley‐Liss, Inc.

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