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Dynamic conformational changes of extracellular S5–P linkers in the hERG channel

✍ Scribed by Min Jiang; Mei Zhang; Innokenty V. Maslennikov; Jie Liu; Dong-Mei Wu; Yuliya V. Korolkova; Alexander S. Arseniev; Eugene V. Grishin; Gea-Ny Tseng


Book ID
110113574
Publisher
Cambridge University Press
Year
2005
Tongue
English
Weight
619 KB
Volume
569
Category
Article
ISSN
0022-3751

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The solution structure of the S4–S5 link
✍ Shovanlal Gayen; Qingxin Li; CongBao Kang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 353 KB

The human ether‐à‐go‐go related gene (hERG) encodes a protein that forms a voltage‐gated potassium channel and plays an important role in the heart by controlling the rapid delayed rectifier K^+^ current (__I__~Kr~). The S4–S5 linker was shown to be important for the gating of the hERG channel. Nucl