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Dynamic Combinatorial Chemistry: The Unexpected Choice of Receptors by Guest Molecules

✍ Scribed by Bas de Bruin; Peter Hauwert; Joost N. H. Reek

Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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Identification of Ligands for the Tau Ex
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## Abstract We describe the use of dynamic combinatorial chemistry (DCC) to identify ligands for the stem‐loop structure located at the exon 10‐5′‐intron junction of Tau pre‐mRNA, which is involved in the onset of several tauopathies including frontotemporal dementia with Parkinsonism linked to chr