Dynamic Combinatorial Chemistry || Index

✍ Scribed by Miller, Benjamin L.

• Publisher: John Wiley & Sons, Inc.
• Year: 2009
• Tongue: English
• Weight: 61 KB
• Edition: 1
• Category: Article
• ISBN: 0470096039
• DOI: 10.1002/9780470551554.index

✦ Synopsis

Effective techniques for applying Dynamic Combinatorial Chemistry

In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.

Chapters cover:

• Basic theory

  • Approaches to binding in proteins and nucleic acids

    • Molecular recognition

      • Self-sorting

        • Catalyst discovery

          • Materials discovery

            • Analytical chemistry challenges

A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.