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Dynamic Analysis of Phosphatase 1B WPD Loop

✍ Scribed by Ozkaral, Burcu; Ozkan, Ahmet; Alakent, Burak; Ozkirimli, Elif

Book ID: 122016461
Publisher: Biophysical Society
Year: 2010
Tongue: English
Weight: 39 KB
Volume: 98
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.2389

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## Abstract The conserved WPD loop of protein tyrosine phosphatases play an important role in the catalytic activity and the invariant aspartate residue acts as a general acid/base catalyst in the dephosphorylation reaction. In our previous report, we have demonstrated that the catalytic activities