Dye-polyethylene glycol 6000 interactions in filmcoating solutions and their effect on color uniformity
✍ Scribed by D. G. Bhatia; T. D. Sokoloski; V. N. Bhatia
- Book ID
- 102913948
- Publisher
- John Wiley and Sons
- Year
- 1966
- Tongue
- English
- Weight
- 525 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The objective of this study was to evaluate the problems of uneven coloration in tablets filmcoated with solutions utilizing polyethylene glycol (PEG 6000) and cellulose acetate phthalate (CAP) in a solvent system consisting of 65 per cent acetone and 3 5 per cent absolute alcohol. It was hypothesized that to obtain uniform color the dye needed to be brought into solution due to interaction between it and one of the other ingredients in the solution. Attention was focused on CAP, PEG 6000, and titanium dioxide.
(u) study of the interaction between dyes, and PEG 6000; (S) study of interaction between dyes and CAP; ( c ) testing of the hypothesis stated above in filmcoating operations; (d) study of the function of titanium dioxide in filmcoating solutions. T h e results show that the interaction of PEG 6000 with the solid dye results in the solubilization of the latter and this is significant in producing uniform color. No interaction was observed between CAP and the dyes. Titanium dioxide was found to act purely me-T h e procedures included the following steps: chanically in preventing the aggregation of dye particles.
NE TYPE of filmcoating solution that is fre-0 quently used utilizes a combination of cellulose acetate phthalate (CAP) and polyethylene glycol 6000 (PEG 6000) as the film former in a solvent system consisting of acetone (65%) and absolute alcohol (35y0). Such a filmcoating solution was described by Gross and Endicott in 1960 (1). While the formula for such a solution consists of a variety of auxiliary agents such as flavoring agents, sweeteners, etc., the basic ingredients are as follows: